Glycéronéogenèse et PEPCK-C

چند شکلی در ژن pepck-c مرغان بومی سیستان

چکیده ژن فسفوانول پیروات کربوکسی کیناز سیتوزولی (pepck-c) یکی از ژنهای کاندیدای مهم می باشد که آنزیم فسفوانول پیروات کربوکسی کیناز را رمزگذاری می کند که آنزیمی مهم در چرخه گلیکونئوژنسیز می باشد. در ژنوم موجودات زنده دو شکل متفاوت از این ژن وجود دارد: ژن فسفوانول پیروات کربوکسی کیناز سیتوزولی (pepck-c ) و ژن نوع میتوکندریایی (pepck-m ). در این تحقیق به طور تصادفی 100 نمونه از دو جمعیت بومی منطق...

PEPCK in cancer cell starvation.

Nutrient and oxygen (O2) deprivation are frequent in solid cancers. Angiogenesis is activated early in cancer growth, however, the newly formed vascular network is aberrant and shows irregular blood flow [1]. Moreover, cancer cells themselves contribute to gradients for nutrients like glucose due to high consumption. The concentration of glucose was estimated to be on average 3 to 10 times lowe...

Liver lipid molecules induce PEPCK-C gene transcription and attenuate insulin action.

Cytosolic phosphoenolpyruvate carboxykinase (PEPCK-C) plays key roles in gluconeogenesis, glyceroneogenesis, and cataplerosis. Experiments were designed to examine the effects of endogenous lipid molecules from rat livers on the expression of PEPCK-C gene in primary rat hepatocytes. The lipid extracts prepared from livers of Zucker fatty, lean, and Wistar rats induced the expression levels of P...

Involvement of KLF11 in Hepatic Glucose Metabolism in Mice via Suppressing of PEPCK-C Expression

BACKGROUND Abnormal hepatic gluconeogenesis is related to hyperglycemia in mammals with insulin resistance. Despite the strong evidences linking Krüppel-like factor 11 (KLF11) gene mutations to development of Type 2 diabetes, the precise physiological functions of KLF11 in vivo remain largely unknown. RESULTS In current investigation, we showed that KLF11 is involved in modulating hepatic glu...

Reply to Leithner et al.: Focus on phopshoenolpyruvate carboxykinase (PEPCK): a target of the p53-SIRT6-FoxO1 axis.